✦ LIBER ✦

Prostate-specific antigen lewels in 1695 men without evidence of prostate cancer: Findings of the American cancer society national prostate cancer detection project

✍ Scribed by Robert A. Kane; Peter J. Littrup; Richard Babaian; Joseph R. Drago; Fred Lee; Arthur Chesley; Gerald P. Murphy; Curtis Mettlin

Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 678 KB
Volume: 69
Category: Article
ISSN: 0008-543X
DOI: 10.1002/cncr.2820690522

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✦ Synopsis

Project is a prospective, multidisciplinary, and multicenter trial to assess the potential for early detection of prostate cancer by transrectal ultrasonography (TRUS), digital rectal examination (DRE), and serum prostate-specific antigen assay (PSA). By November 1990, 2805 men between the ages of 55 and 70 years with no known signs or symptoms of prostate cancer were enrolled in the study, which is planned to run for 5 years. Annual TRUS, DRE, and PSA tests were done on these subjects, and biopsies were recommended for suspicious lesions when detected. To study the performance of PSA testing in presumed normal subjects, all men were eliminated who had (1) prostate cancer detected on their initial examinations and proven by biopsy or (2) cancer detected during the year or subsequent examinations. Additionally, all men with TRUS or DRE findings that were interpreted as suspicious for cancer but who are being followed and have not yet had biopsies done were removed from this series. This left a unique, extensively screened group of 1695 men who were free of prostate cancer, as From the

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