Prostate-specific antigen and prostate gland volume: Correlation and clinical application

✍ Scribed by R. Joseph Babaian; Robert B. Evans; Herbert A. Fritsche

• Publisher: John Wiley and Sons
• Year: 1990
• Tongue: English
• Weight: 304 KB
• Volume: 4
• Category: Article
• ISSN: 0887-8013
• DOI: 10.1002/jcla.1860040212

✦ Synopsis

We studied 103 patients seen in our Prostate Cancer Detection Clinic to determine whether a correlation exists between serum prostate-specific antigen (PSA) values and ultrasound-calculated prostate gland volume. Seventy men (68%) had a PSA value s 4 ngiml (our upper limit of normal). The men were subclassified by prostate gland volume at arbitrary break points. Twenty-five men (24%) had a prostate gland volume ~2 5 cm3; in 96%, the PSA value was s 4 mgiml. Further analysis revealed that the percentage of men with a normal serum PSA value decreased a s the prostate gland volume increased; 65.6% of the group with a gland volume between 25 and 50 cm3 (40 of 61) and 35.5% of the group whose prostate volume exceeded 50 cm3 (6 of 17) had PSA values 514 ngiml. Four men had PSA values >20 ngiml; all had prostate cancer. Cancer was diagnosed in four additional patients, three with PSA values between 5 and 10 ngiml and one with a PSA value <4 ngiml. There appears to be a direct relationship between prostate gland volume and PSA value, as well as a cancer value threshold. The clinical implications of these findings are discussed.