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Prostanoids: LXXXIII. Synthesis of (±)-19-Carboxy-20-norprostaglandin F2α and Its 15β-Epimer

✍ Scribed by R. R. Akhmetvaleev; F. A. Akbutina; T. A. Belogaeva; O. V. Shitikova; M. S. Miftakhov


Book ID
110349997
Publisher
SP MAIK Nauka/Interperiodica
Year
2002
Tongue
English
Weight
62 KB
Volume
38
Category
Article
ISSN
1070-4280

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✍ Francisco S. Alvarez; Douglas Wren 📂 Article 📅 1973 🏛 Elsevier Science 🌐 French ⚖ 211 KB

We wish to report an efficient synthesis of 11-deoxy PGElg, 11-deoxy PGFlc, and ll-deoxy PGFl5 and its 158 epimers via the key intermediate 2-(6'-carbomethoxyhexyl)-cyclopenten-1-one-3-carboxaldehyde (6). Michael addition of nitromethane to the ketone 1 7a , catalyzed with tetra-2 methylguanidine ,