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Prostaglandins. X. Synthesis of prostaglandin models and prostaglandins by conjugage addition of a functionalized organocopper reagent

✍ Scribed by Kluge, Arthur F.; Untch, Karl G.; Fried, John H.

Book ID
121319387
Publisher
American Chemical Society
Year
1972
Tongue
English
Weight
824 KB
Volume
94
Category
Article
ISSN
0002-7863

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Prostaglandin H synthases (PGHSs) are heme-containing enzymes, which directly add two O 2 molecules to arachidonic acid (AA) by the initiation of H-atom abstraction of 1,4-diene moiety and through sequential reactions to give PGH 2 as a final product. Here, we report the synthesis of a new PGHS mode