Prostaglandins in the brain of rats given, acutely, and chronically, a hyperthermic dose of met-enkephalin

✍ Scribed by G. M. Scoto; C. Spadaro; S. Spampinato; R. Arrigo-Reina; S. Ferri

• Book ID: 104771776
• Publisher: Springer
• Year: 1979
• Tongue: English
• Weight: 273 KB
• Volume: 60
• Category: Article
• ISSN: 0033-3158
• DOI: 10.1007/bf00432297

✦ Synopsis

An enhanced prostaglandinlike activity is shown in homogenates of brain from rats treated intracerebroventricularly with 100 microgram of metenkephalin. The increase is significantly reduced by naloxone pretreatment. A relationship is proposed between generation of prostaglandins in the brain following met-enkephalin administration and hyperthermic effect of the opiatelike factor in the rat. Normalization of prostaglandinlike activity following chronic administration of met-enkephalin in the rat may also account for the development of tolerance to its thermic effect.