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Prostaglandins and human platelet aggregation: Implications for the anti-aggregating activity of thromboxane-synthase inhibitors

✍ Scribed by Grazyna Rajtar; Chiara Cerletti; Maria Novella Castagnoli; Vittorio Bertelé; Giovanni de Gaetano


Book ID
115777988
Publisher
Elsevier Science
Year
1985
Tongue
English
Weight
469 KB
Volume
34
Category
Article
ISSN
0006-2952

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The pharmacokinetics and pharmacologic effects of a potent, selective inhibitor of thromboxane synthetase, CV-4151 [(E)-7-phenyl-7-(3-pyridyl)-6-heptenoic acid] on prostanoid formation and platelet aggregation were studied in 42 healthy male volunteers. The drug was well tolerated. After oral admini