𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Prostaglandins and congeners I. The synthesis of 11,15-bisdeoxyprostaglandins E1, E2, and F1α. The stereospecific conjugate addition of a lithium trans-1-alkenylalanate.

✍ Scribed by Karel F. Bernady; Martin J. Weiss


Publisher
Elsevier Science
Year
1972
Tongue
French
Weight
164 KB
Volume
13
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


Prostaglandins and congeners VIII. An im
✍ Karel F. Bernady; John F. Poletto; Martin J. Weiss 📂 Article 📅 1975 🏛 Elsevier Science 🌐 French ⚖ 191 KB

Recent communications from these laboratories have described a new and useful procedure for the synthesis of prostaglandins based upon the conjugate addition to cyclopentenones of E-lalkenyl ligands from lithium E-1-alkenyltrialkylalanate reagents.\* The preparation of these alanate reagents require

Synthesis of (±) 11-deoxyprostaglandin E
✍ Francisco S. Alvarez; Douglas Wren 📂 Article 📅 1973 🏛 Elsevier Science 🌐 French ⚖ 211 KB

We wish to report an efficient synthesis of 11-deoxy PGElg, 11-deoxy PGFlc, and ll-deoxy PGFl5 and its 158 epimers via the key intermediate 2-(6'-carbomethoxyhexyl)-cyclopenten-1-one-3-carboxaldehyde (6). Michael addition of nitromethane to the ketone 1 7a , catalyzed with tetra-2 methylguanidine ,