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Prostaglandin receptor EP2 protects dopaminergic neurons against 6-OHDA-mediated low oxidative stress

โœ Scribed by Emilce Carrasco; Peter Werner; Diana Casper


Book ID
116770548
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
603 KB
Volume
441
Category
Article
ISSN
0304-3940

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PGE2 receptor EP1 renders dopaminergic n
โœ Emilce Carrasco; Diana Casper; Peter Werner ๐Ÿ“‚ Article ๐Ÿ“… 2007 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 273 KB ๐Ÿ‘ 1 views

Oxidative stress and increased cyclooxygenase-2 (COX-2) activity are both implicated in the loss of dopaminergic neurons from the substantia nigra (SN) in idiopathic Parkinson's disease (PD). Prostaglandin E 2 (PGE 2 ) is one of the key products of COX-2 activity and PGE 2 production is increased in