Prostaglandin production in chronic progressive multiple sclerosis

✍ Scribed by Judith A. Aberg; Laurence M. Demers; Paula J. Romano; Richard B. Tenser

• Publisher: John Wiley and Sons
• Year: 1990
• Tongue: English
• Weight: 430 KB
• Volume: 4
• Category: Article
• ISSN: 0887-8013
• DOI: 10.1002/jcla.1860040403

✦ Synopsis

Abstract

Peripheral blood monocytes have been implicated in the immune reactions that accompany demyelination in patients with multiple sclerosis (MS). We measured prostaglandin E~2~ (PGE~2~) and thromboxane B~2~ (TxB~2~) release from peripheral monocytes exposed in vitro to complement. Our studies suggest that there is a significantly higher production of PGE~2~ in monocytes from patients with chronic progressive MS than in those with exacerbation or remitting MS and healthy controls. No significant differences in TxB~2~release were noted between the three groups.