✦ LIBER ✦
Prostaglandin prodrugs I: Stabilization of dinoprostone (prostaglandin E2) in solid state through formation of crystalline C1-phenyl esters
✍ Scribed by W. Morozowich; T. O. Oesterling; W. L. Miller; C. F. Lawson; J. R. Weeks; R. G. Stehle; S. L. Douglas
- Publisher
- John Wiley and Sons
- Year
- 1979
- Tongue
- English
- Weight
- 405 KB
- Volume
- 68
- Category
- Article
- ISSN
- 0022-3549
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✦ Synopsis
Dinoprostone para-substituted phenyl esters were synthesized in attempt to improve the solid-state stability of the parent prostaglandin. A phenol series covering a wide melting-point range was employed, and a linear relationship was observed between the phenol melting points and the resulting prostaglandin C1-ester melting points. The crystalline esters showed improved solid-state stability over the parent compound, and many esters were biologically active.