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Prostaglandin H Synthase Expression Is Variable in Human Colorectal Adenocarcinoma Cell Lines

✍ Scribed by Judy Parker; Mike K. Kaplon; Consuelo J. Alvarez; Guha Krishnaswamy


Book ID
115602799
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
301 KB
Volume
236
Category
Article
ISSN
0014-4827

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Expression of microsomal prostaglandin E
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Gastrointestinal carcinomas synthesize elevated levels of prostaglandin E(2) (PGE(2)), which has been mechanistically linked to carcinogenesis. Recently, microsomal prostaglandin E synthase-1 (mPGES-1) was cloned, which seems to be inducible and linked to cyclooxygenase-2 (Cox-2) in the biosynthesis