Prostaglandin F2α stimulates phosphatidylinositol turnover and increases the cellular content of 1,2-diacylglycerol in confluent resting swiss 3T3 cells

Mevalonate dependency of the early cell

Mevalonate dependency of the early cell cycle mitogenic response to epidermal growth factor and prostaglandin F2α in Swiss mouse 3T3 cells

✍ Marcela B. Ortiz; Mercedes Goin; Maria B. Gomez de Alzaga; Swen Hammarstrom; Lui 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 778 KB

Lovastatin (LOV), a hydroxy-methylglutaryl-coenzyme A (HMGCoA) reductase competitive inhibitor, blocks epidermal growth factor (EGF)or prostaglandin F , , (PGF,,)-induced mitogenesis in confluent resting Swiss 3T3 cells. This inhibition occurs even in the presence of insulin, which potentiates the a