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Prostaglandin F2α decreases the affinity of epidermal growth factor receptors in Swiss mouse 3T3 cells via protein kinase C activation

✍ Scribed by Luis Jimenez de Asua; Mercedes Goin


Book ID
115925821
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
425 KB
Volume
299
Category
Article
ISSN
0014-5793

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Lovastatin (LOV), a hydroxy-methylglutaryl-coenzyme A (HMGCoA) reductase competitive inhibitor, blocks epidermal growth factor (EGF)or prostaglandin F , , (PGF,,)-induced mitogenesis in confluent resting Swiss 3T3 cells. This inhibition occurs even in the presence of insulin, which potentiates the a