Prostaglandin F2α activates protein kinase C in human ovarian cells
✍ Scribed by Abayasekara, D.R.E.; Jones, P.M.; Persaud, S.J.; Michael, A.E.; Flint, A.P.F.
- Book ID
- 122467446
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 837 KB
- Volume
- 91
- Category
- Article
- ISSN
- 0303-7207
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## Abstract We previously reported that prostaglandin F~2α~ (PGF~2α~) receptor is coupled to pertussis toxin (PTX)–sensitive GTP‐binding protein (G protein) in osteoblast‐like MC3T3‐E1 cells [Miwa et al. (1990): Biochem Biophys Res Commun 171:1229–1235]. In the present study, we examined the effect
In cloned osteoblast-like cells, MC3T3-EII prostaglandin F, , (PGF,,) stimulated arachidonic acid (AA) release in a dose-dependent manner in the range between 1 n M and 10 pM. 12-O-tetradecanoylphorbol-l3-acetate (TPA), a protein kinase C (PKC) activator, which by itself had little effect on AA rele