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Prostaglandin E2 has antinociceptive effect through EP1 receptor in the ventromedial hypothalamus in rats

โœ Scribed by Masako Hosoi; Takakazu Oka; Michie Abe; Tetsuro Hori; Hiroshi Yamamoto; Kazunori Mine; Chiharu Kubo


Book ID
117480347
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
148 KB
Volume
83
Category
Article
ISSN
0304-3959

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It is generally accepted that prostaglandins (PGs) are nociceptive substances. However, earlier studies from this laboratory indicated that morphine analgesia, in the rat, was not only serotonin mediated, but involved PGs as well. Several PG synthesis inhibitors were shown to inhibit morphine analge