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Prostaglandin E2 couples through EP4 prostanoid receptors to induce IL-8 production in human colonic epithelial cell lines

✍ Scribed by I Dey; MA Giembycz; K Chadee

Book ID: 111218096
Publisher: Nature Publishing Group
Year: 2009
Tongue: English
Weight: 492 KB
Volume: 156
Category: Article
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.2008.00056.x

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## Abstract Matrix metalloproteinase‐1 (MMP‐1, collagenase‐1) plays a pivotal role in the process of joint destruction in degenerative joint diseases. We have examined the regulation of MMP‐1 production in human chondrocytic HCS‐2/8 cells stimulated by tumor necrosis factor‐α (TNF‐α). In response t