Prostaglandin E1 protects against liver injury induced by Escherichia coli infection via a dominant th2-like response of liver T cells in mice
✍ Scribed by Yasuji Mokuno; Manabu Takano; Tetsuya Matsuguchi; Hitoshi Nishimura; Junji Washizu; Yoshikazu Naiki; Yuji Nimura; Yasunobu Yoshikai
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 676 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0270-9139
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✦ Synopsis
Prostaglandin E series (PGEs) are known to protect against lipopolysaccharide (LPS)-induced liver injury by down-regulating the production of inflammatory cytokines. We show here a novel mechanism whereby prostaglandin E 1 protects mice against liver injury after Escherichia coli infection. Prostaglandin E 1 administration suppressed circulating interleukin 12 (IL-12) levels but increased the IL-10 production after E. coli challenge. Furthermore, prostaglandin E 1 -␣-cyclodextrin (PGE 1 ) shifted the Th1/Th2 balance of CD3 intermediate IL-2R ؉ T cells in the liver to a dominant Th2-like response. Neutralization of endogenous IL-4 by administration of anti-IL-4 monoclonal antibody (mAb) diminished the inhibitory effect of prostaglandin E 1 on liver injury after E. coli challenge. These results suggested that the Th2-like response of liver T cells may be at least partly involved in the mechanism whereby prostaglandin E 1 protects against E. coli-induced liver injury. (HEPATOLOGY 1999; 30:1464-1472.