Expression of microsomal prostaglandin E
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M. Westman; M. Korotkova; E. af Klint; A. Stark; L. P. Audoly; L. Klareskog; A.-
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Article
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2004
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John Wiley and Sons
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English
β 372 KB
Objective. Microsomal prostaglandin E synthase 1 (mPGES-1) catalyzes the formation of PGE 2 from cyclooxygenase-derived PGH 2 . Microsomal PGES-1 is induced by proinflammatory cytokines and is strongly linked to conditions that result in high PGE 2 biosynthesis. PGE 2 contributes to the pathogenesis