Prostacyclin and Its Receptors

✍ Scribed by Helen Wise, Robert L. Jones (auth.)

• Publisher: Springer US
• Year: 2002
• Tongue: English
• Leaves: 314
• Edition: 1
• Category: Library

✦ Synopsis

In addition to its well known anti-platelet and hypotensive properties, prostacyclin activates neuronal receptors in the central, enteric and sensory nervous systems. This volume discusses the properties of prostacyclin receptors in the cardiovascular and nervous systems, as well as in cells involved in inflammatory reactions. The chemistry and pharmacology of prostacyclin mimetics are also explored, higlighting their therapeutic value.

✦ Table of Contents

An introduction to prostacyclin and its receptors....Pages 1-27
The development of prostacyclin analogues....Pages 29-58
Nonprostanoid prostacyclin mimetics....Pages 59-78
Isolation, cloning and characterisation of IP-receptors....Pages 79-108
IP-receptors on platelets....Pages 109-139
IP-receptors in the vasculature....Pages 137-188
IP-receptors on neutrophils....Pages 189-214
IP-receptors on monocytes/macrophages and lymphocytes....Pages 215-242
IP-receptors on sensory neurones....Pages 243-270
IP-receptors in the enteric nervous system....Pages 271-284
IP-receptors in the central nervous system....Pages 285-304

✦ Subjects

Pharmacology/Toxicology; Biochemistry, general; Neurology; Neurosciences