Construction of mammalian artificial chr
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Dirk Schindelhauer
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Article
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1999
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John Wiley and Sons
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English
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Two reports have shown that mammalian artificial chromosomes (MAC) can be constructed from cloned human centromere DNA and telomere repeats, proving the principle that chromosomes can form from naked DNA molecules transfected into human cells. The MACs were mitotically stable, low copy number and bo