Prospective study of cutaneous phototoxicity after systemic hematoporphyrin derivative

✍ Scribed by Robert S. Wooten; Kevin C. Smith; David A. Ahlquist; Sigfrid A. Muller; Rita K. Balm

• Book ID: 102934241
• Publisher: John Wiley and Sons
• Year: 1988
• Tongue: English
• Weight: 651 KB
• Volume: 8
• Category: Article
• ISSN: 0196-8092
• DOI: 10.1002/lsm.1900080312

✦ Synopsis

Hematoporphyrin derivative (HpD) is a photoactiw, oncophilic substance that produces cutaneous photosensitivity as ils only significant side effect. Twenty-three patients who received systemic HpD and the usual light-avoidance precautions were studied prospectively to determine the incidence and severity of cutaneous phototoxicity (CP). Seventeen of the 23 patients (74%) reported CF', including three patients (18% I who experienced blister formation. Symptoms of CP occurred for a mean duration of' 6 weeks (range 5-23 weeks). Lack of compliance with restrictive photoprotective measures was felt to be a major contributing factor. Other HpD-related complications included skin hyperpigmentation, ocular discomfort, pruritus, pain at injection site, and urticaria. C P and the restrictive measures to avoid it represent major disadvantages of the clinical use of HpD.