𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Prospective randomized study of hyperthermia combined with chemoradiotherapy for esophageal carcinoma

✍ Scribed by Kaoru Kitamura; Hiroyuki Kuwano; Masayuki Watanabe; Tadahiro Nozoe; Mitsuhiro Yasuda; Kohei Sumiyoshi; Motonori Saku; Keizo Sugimachi

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
386 KB
Volume
60
Category
Article
ISSN
0022-4790

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

From January 1988 to June 1992, 66 patients with resectable squamous cell carcinoma of the thoracic esophagus underwent preoperative adjuvant therapy. These patients were prospectively divided into two treatment groups; 32 were treated with radiofrequency wave local hyperthermia combined with chemoradiotherapy (hyperthermochemoradiotherapy; HCR), while the remaining 34 patients were treated with chemoradiotherapy alone (CR).

There were no procedural complications in either group and the postoperative mortality was zero. In the HCR group, no viable cancer cells were found within the entire 5 mm‐width slices of the resected specimen in eight patients (25%), while only two (5.9%) in the CR group (P < 0.05) demonstrated no viable cancer cells. The cumulative 3‐year survival rate was 50.4% in the HCR group and 24.2% in the CR group.

The present prospective trial demonstrated that the addition of hyperthermia to chemoradiotherapy resulted in a better local control and an improved long‐term survival when treating patients with advanced esophageal carcinoma. Β© 1995 Wiley‐Liss, Inc.

πŸ“œ SIMILAR VOLUMES

A Prospective Randomized Study of Two Sc
A Prospective Randomized Study of Two Sclerotherapy Techniques for Esophageal Varices
✍ David Westaby; Brian R. D. Macdougall; Walter Melia; Andrew Theodossi; Roger Wil πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 English βš– 440 KB

In a study designed to compare the efficacy and safety of two techniques of injection sclerotherapy, 40 patients (30 with cirrhosis and 10 with portal vein block) were randomly allocated to the sheath or free-hand technique. Although the former was associated with significantly less bleeding within

A prospective longitudinal study examini
A prospective longitudinal study examining the quality of life of patients with esophageal carcinoma
✍ Jane M. Blazeby; John R. Farndon; Jenny Donovan; Derek Alderson πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 English βš– 118 KB πŸ‘ 3 views

## Background: Quality of life (ql) measurement provides detailed information about outcome from the patient's perspective. this study assessed the impact on short and long term ql of esophagectomy and palliative treatment in patients with esophageal carcinoma. ## Methods: Consecutive patients un

Somatostatin alone or combined with emer
Somatostatin alone or combined with emergency sclerotherapy in the treatment of acute esophageal variceal bleeding: A prospective randomized trial
✍ CΓ ndid Villanueva; Jordi Ortiz; Miriam SΓ bat; Adolfo Gallego; Xavier Torras; Ger πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 101 KB

trials have shown that somatostatin (SMT) is as effective as sclerotherapy in the treatment of acute variceal bleeding and that the combination of both treatments is more effective than sclerotherapy alone. To assess whether the addition of sclerotherapy improves the efficacy of SMT alone, all patie

Radiotherapy alone or combined with carb
Radiotherapy alone or combined with carbogen breathing for squamous cell carcinoma of the head and neck : A prospective, randomized trial
✍ William M. Mendenhall; Christopher G. Morris; Robert J. Amdur; Nancy P. Mendenha πŸ“‚ Article πŸ“… 2005 πŸ› John Wiley and Sons 🌐 English βš– 141 KB πŸ‘ 2 views

## Abstract ## BACKGROUND The current study was performed to investigate the efficacy of carbogen (95% oxygen [O~2~] and 5% carbon dioxide [CO~2~]) breathing during definitive radiotherapy (RT) to enhance local control. ## METHODS Between November 1996 and November 2002, 101 patients with previo