Prospective Randomized Evaluation of a Collagen/Thrombin and Autologous Platelet Hemostatic Agent During Total Knee Arthroplasty

✍ Scribed by Michael R. Bloomfield; Alison K. Klika; Robert M. Molloy; Mark I. Froimson; Viktor E. Krebs; Wael K. Barsoum

• Book ID: 113469217
• Publisher: Elsevier Science
• Year: 2012
• Tongue: English
• Weight: 267 KB
• Volume: 27
• Category: Article
• ISSN: 1532-8406
• DOI: 10.1016/j.arth.2011.09.014

✦ Synopsis

The purpose of this study was to evaluate the effectiveness of a collagen/thrombin and autologous platelet hemostatic agent in preventing blood loss during primary total knee arthroplasty. This prospective, double-blinded, randomized study was designed to enroll a total of 100 patients. Patients were randomized 1:1 to either the treatment arm (standard hemostasis plus study product) or the control arm (standard hemostasis alone). Transfusion requirements, as determined by a blinded investigator using standardized criteria, were significantly lower in the treatment group (no blood transfusions) compared with the control group (5 transfusions; P = .007). These data support the addition of the study product to prevent blood transfusions after primary total knee arthroplasty.