Prospective evaluation of risk factors for the development of islet autoimmunity and type 1 diabetes during puberty – TEENDIAB: study design
✍ Scribed by Anette-Gabriele Ziegler; Franziska Meier-Stiegen; Christiane Winkler; Ezio Bonifacio; the TEENDIAB Study Group
- Book ID
- 115100434
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 534 KB
- Volume
- 13
- Category
- Article
- ISSN
- 1399-543X
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Genetic determination as well as prospective analysis of islet cell autoantibodies and autoantibodies to insulin were conducted in a population of 479 first degree relatives of 174 Type 1 (insulin-dependent) diabetic patients. Analysis of HLA haplotypes within families illustrated the high frequency
To evaluate the behaviour and predictive value of islet cell and insulin autoantibodies in patients with organ-specific autoimmune diseases, we followed 21 non-diabetic subjects for a mean period of 84 +/- 27 months. Ten patients were persistently seropositive for complement-fixing islet cell antibo