Prospective controlled trial of selective parenteral and enteral antimicrobial regimen in fulminant liver failure

✍ Scribed by Nancy Rolando; Alexander Gimson; Jim Wade; John Philpott-Howard; Mark Casewell; Roger Williams

• Publisher: John Wiley and Sons
• Year: 1993
• Tongue: English
• Weight: 622 KB
• Volume: 17
• Category: Article
• ISSN: 0270-9139
• DOI: 10.1002/hep.1840170206

✦ Synopsis

To compare the efficacy of a selective parenteral and enteral antimicrobial regimen in patients with fulminant liver failure, we classified 104 patients on reaching grade I1 encephalopathy as infected or noninfected. Patients who were infected were randomly assigned to receive IV cefuroxime (group 1) or selective parenteral and enteral antimicrobial regimen (group 2). Noninfected patients were randomly selected to receive either selective parenteral and enteral antimicrobial regimen (group 3) or no initial antimicrobials until clinically indicated (group 4). The four groups were comparable regarding age, sex, cause of disease, coma grade, international normalization ratio, presence of kidney failure and indicators of poor prognosis on admission to the study. Clinical parameters such as white cell count, temperature or changes