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Propylene oxide: mutagenesis, carcinogenesis and molecular dose

✍ Scribed by Melva N Rı́os-Blanco; Kamila Plna; Thomas Faller; Winfried Kessler; Krystyna Håkansson; Paul E Kreuzer; Asoka Ranasinghe; Johannes G Filser; Dan Segerbäck; James A Swenberg

Book ID
114071335
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
217 KB
Volume
380
Category
Article
ISSN
0027-5107

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📜 SIMILAR VOLUMES

Propylene oxide mutagenesis at template
Propylene oxide mutagenesis at template cytosine residues
✍ Elizabeth T. Snow; Jatinder Singh; Karen L. Koenig; Jerome J. Solomon 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 689 KB

Propylene oxide (PO) is a widely used industrial reagent which is mutagenic and carcinogenic. We have recently shown that a variety of aliphatic epoxides, including propylene oxide, can reoct with DNA to form hydroxyalkyl adducts at N-3 of cytosine which rapidly undergo hydrolytic deamination to pr