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Proprotein Convertases in Tumor Progression and Malignancy: Novel Targets in Cancer Therapy

✍ Scribed by Abdel-Majid Khatib; Géraldine Siegfried; Michel Chrétien; Peter Metrakos; Nabil G. Seidah


Book ID
117021116
Publisher
American Society for Investigative Pathology
Year
2002
Tongue
English
Weight
484 KB
Volume
160
Category
Article
ISSN
0002-9440

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Proprotein convertases (PCs) are a group of Ca 2þ -dependent serine proteases that have homology to the endoproteases subtilisin (bacteria) and kexin (yeast). This group is comprised of less than a dozen members, known as furin/PACE, PC1/PC3, PC2, PC4, PACE4, PC5/PC6, PC7/PC8/LPC, SKI/S1P, and NARC-

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