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Propranolol induces hyperreactivity in lung parenchyma strips from sensitized guinea pigs

✍ Scribed by Mario H. Vargas; Dr. Luis M. Montaño; Beatriz Vanda; Moisés Selman

Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
354 KB
Volume
17
Category
Article
ISSN
0272-4391

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✦ Synopsis

Propranolol induces hyperreactivity in lung parenchyma strips from sensitized guinea pigs. Drug Dev. Res., 17~135-140, 1 989.

Propranolol causes airway hyperreactivity to agonists or antigenic challenge in vivo, but its mechanisms are still debated. In this study we found that the addition of propranolol (10 p,g/ml) to lung parenchyma strips from sensitized guinea pigs enhanced the sensitivity and maximum contraction to antigenic challenge (ovalbumin, 0.01-1 00 pgiml) and the sensitivity to histamine (1 x 1 0-7 to 1.7 x 1 OP4 M), determined through concentration-response curves. In contrast, tracheal chains from sensitized guinea pigs were unaffected. These results in in vitro preparations strongly suggest that, at least in lung parenchyma tissue, other mechanisms different from beta-blockade are present in propranolol-induced airway hyperreactivity.

📜 SIMILAR VOLUMES

Non-specific Airway Hyperreactivity in I
Non-specific Airway Hyperreactivity in Isolated Respiratory Preparations from Guinea-pigs Sensitized and Challenged with Ovalbumin
✍ C.A. Lewis; D. Raeburn; K.J. Broadley 📂 Article 📅 1994 🏛 Elsevier 🌐 English ⚖ 417 KB

SUMMARY: Airway hyperreactivity to physical, chemical, immunological and pharmacological stimuli is well documented in vivo. The aim of this study was to investigate whether tissues taken from guinea-pigs that had been shown to display hyperreactivity in vivo after antigen challenge were also hyperr