Propranolol for portal hypertensive gastropathy: Another virtue of β-blockade?
✍ Scribed by Santiago J. Muñoz
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 424 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0270-9139
No coin nor oath required. For personal study only.
✦ Synopsis
HEPATOLOGY Elsewhere HEPATOI.OGY given late in the course of the hepatic necrosis. The similarity in beneficial effects of prostacyclin with N-acetylcysteine may be the result of the fact that prostacyclin is also known to inhibit platelet aggregation, reduce production and release of proinflammatory cytokines and maintain vascular patency. Unfortunately, the authors have not provided any data to either support or refute this contention, and therefore this conclusion is not warranted at this time.
Nevertheless, the findings of this study are potentially interesting and may provide insights into the mechanism for the reported beneficial effect of late administration of acetylcysteine in acetaminophen-induced FHF. However, controlled studies are required before one can indeed conclude that late infusion of acetylcysteine is of benefit in the treatment of patients with acetaminophen overdose.