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Proposed role for the α2 chain in resolving an ambiguity in self — Assembly of the collagen fibril

✍ Scribed by David W.L. Hukins; John Woodhead-Galloway


Book ID
118311125
Publisher
Elsevier Science
Year
1976
Tongue
English
Weight
234 KB
Volume
70
Category
Article
ISSN
0006-291X

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Role of the pro-α2(I) COOH-terminal regi
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Procollagen (Type I) contains a noncollagenous COOH-terminal propeptide (C-propeptide) hypothesized to be important in directing chain association and alignment during assembly. We previously expressed human pro-␣2(I) cDNA in rat liver epithelial cells, W8, that produce only pro-␣1(I) trimer collage

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Collagen biosynthesis is a complex process that begins with the association of three procollagen chains. A series of conserved intra-and interchain disulfide bonds in the carboxyl-terminal region of the procollagen chains, or C-propeptide, has been hypothesized to play an important role in the nucle