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Proposed Mechanism of Action of Hydrolytic Enzymes

โœ Scribed by CUNNINGHAM, L. W.


Book ID
121149626
Publisher
American Association for the Advancement of Science
Year
1957
Tongue
English
Weight
338 KB
Volume
125
Category
Article
ISSN
0036-8075

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Hypothesis: Thalidomide embryopathy?prop
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We propose that thalidomide affects the following pathway during limb development: Growth factors (FGF-2 and IGF-I) attach to receptors on limb bud mesenchymal cells and initiate some second messenger system (perhaps SP-1), which activates โฃv and โค3 integrin subunit genes. The resulting โฃv โค3 integr