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Proposal of a novel diabetogenic mechanism involving the serpin PAI-1

✍ Scribed by Sarah L. Griffiths; David J. Grainger

Publisher: John Wiley and Sons
Year: 2006
Tongue: English
Weight: 356 KB
Volume: 28
Category: Article
ISSN: 0265-9247
DOI: 10.1002/bies.20418

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✦ Synopsis

Abstract

Metabolic Syndrome is a cluster of risk factors (including obesity, hypertension and insulin resistance), which is associated with late‐onset diabetes and coronary heart disease. Elevated levels of the protease inhibitor PAI‐1 are well‐known molecular markers of the Metabolic Syndrome. Here, however, we present a hypothesis that PAI‐1 acts as a causative factor in the development of Metabolic Syndrome and its clinical sequelae. We propose that PAI‐1 inhibits the activity of members of the proprotein convertase (PC) class of serine proteases and that this underlies, at a molecular level, many of the other features of the Metabolic Syndrome cluster. BioEssays 28: 629–641, 2006. © 2006 Wiley Periodicals, Inc.

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