Propionic acid production by extractive fermentation. I. Solvent considerations

✍ Scribed by Zhong Gu; Bonita A. Glatz; Charles E. Glatz

• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 165 KB
• Volume: 57
• Category: Article
• ISSN: 0006-3592
• DOI: 10.1002/(sici)1097-0290(19980220)57:4<454::aid-bit9>3.0.co;2-l

✦ Synopsis

Solvent selection for extractive fermentation for propionic acid was conducted with three systems: Alamineா 304-1 (trilaurylamine) in 2-octanol, 1dodecanol, and Witcoholா 85 NF (oleyl alcohol). Among them, the solvent containing 2-octanol exhibited the highest partition coefficient in acid extraction, but it was also toxic to propionibacteria. The most solvent-resistant strain among five strains of the microorganism was selected. Solvent toxicity was eliminated via two strategies: entrapment of dissolved toxic solvent in the culture growth medium with vegetable oils such as corn, olive, or soybean oils; or replacement of the toxic 2-octanol with nontoxic Witcohol 85 NF. The complete recovery of acids from the Alamine 304-1/Witcohol 85 NF was also realized with vacuum distillation.