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Propionic Acid Induces Cytoskeletal Alterations in Cultured Astrocytes From Rat Cerebral Cortex

✍ Scribed by Lúcia Maria Vieira de Almeida; Cláudia Funchal; Carmem Gottfried; Moacir Wajner; Regina Pessoa-Pureur

Publisher
Springer
Year
2006
Tongue
English
Weight
780 KB
Volume
21
Category
Article
ISSN
0885-7490

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Evidence that the branched-chain α-keto acids accumulating in maple syrup urine disease induce morphological alterations and death in cultured astrocytes from rat cerebral cortex
✍ Cláudia Funchal; Carmem Gottfried; Lúcia Maria Vieira De Almeida; Moacir Wajner; 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 609 KB

## Abstract Severe neurological symptoms, cerebral edema, and atrophy are common features of the inherited metabolic disorder maple syrup urine disease (MSUD). However, the pathomechanisms involved in the neuropathology of this disease are not well established. In this study, we investigated the ef