We conducted a Phase II study of PROMACE-MOPP and intrathecal (IT) therapy followed by cranial radiation in 7 patients (4 male, 3 females) with diffuse large cell lymphomas (including one T cell) involving the central nervous system (CNS). Median age was 47 years (range, 25-78). Median performance s
✦ LIBER ✦
Prophylactic intrathecal chemotherapy in primary CNS lymphoma
✍ Scribed by Monica Sierra del Rio; Damien Ricard; Caroline Houillier; Soledad Navarro; Alberto Gonzalez-Aguilar; Ahmed Idbaih; Gentian Kaloshi; Soufiane Elhallani; Antonio Omuro; Sylvain Choquet; Carole Soussain; Khé Hoang-Xuan
- Publisher
- Springer US
- Year
- 2011
- Tongue
- English
- Weight
- 216 KB
- Volume
- 106
- Category
- Article
- ISSN
- 0167-594X
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## Abstract Epigenetic silencing of functionally important genes is important in the development of malignancies and is a source of potential markers for molecular detection. Primary central nervous system lymphoma (PCNSL) is an increasingly common tumor that has not been extensively examined for c