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Prophylactic effects of chitin microparticles on highly pathogenic H5N1 influenza virus

✍ Scribed by Takeshi Ichinohe; Noriyo Nagata; Peter Strong; Shin-ichi Tamura; Hidehiro Takahashi; Ai Ninomiya; Masaki Imai; Takato Odagiri; Masato Tashiro; Hirofumi Sawa; Joe Chiba; Takeshi Kurata; Tetsutaro Sata; Hideki Hasegawa

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
155 KB
Volume
79
Category
Article
ISSN
0146-6615

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Highly pathogenic avian influenza virus (H5N1) is an emerging pathogen with the potential to cause great harm to humans, and there is concern about the potential for a new influenza pandemic. This virus is resistant to the antiviral effects of interferons and tumor necrosis factor‐α. However, the mechanism of interferon‐independent protective innate immunity is not well understood. The prophylactic effects of chitin microparticles as a stimulator of innate mucosal immunity against a recently obtained strain of H5N1 influenza virus infection were examined in mice. Clinical parameters and the survival rate of mice treated by intranasal application of chitin microparticles were significantly improved compared to non‐treated mice after a lethal influenza virus challenge. Flow cytometric analysis revealed that the number of natural killer cells that expressed tumor necrosis factor‐related apoptosis‐inducing ligand (TRAIL) and that had migrated into the cervical lymph node was markedly increased (26‐fold) after intranasal treatment with chitin microparticles. In addition, the level of IL‐6 and interferon‐gamma‐inducible protein‐10 (IP‐10) in the nasal mucosa after H5N1 influenza virus challenge was decreased by prophylactic treatment with chitin microparticles. These results suggest that prophylactic intranasal administration of chitin microparticles enhanced the local accumulation of natural killer cells and suppressed hyper‐induction of cytokines, resulting in an innate immune response to prevent pathogenesis of H5N1 influenza virus. J. Med. Virol. 79: 811–819, 2007. © 2007 Wiley‐Liss, Inc.

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