Prophylactic cefazolin in amnioinfusions administered for meconium-stained amniotic fluid

✍ Scribed by R.K. Edwards; P. Duff

• Book ID: 101262943
• Publisher: Hindawi Publishing Corporation
• Year: 1999
• Tongue: English
• Weight: 56 KB
• Volume: 7
• Category: Article
• ISSN: 1064-7449
• DOI: 10.1002/(sici)1098-0997(1999)7:3<153::aid-idog7>3.0.co;2-2

✦ Synopsis

Objective: To determine if amnioinfusion with an antibiotic solution decreased the rate of clinical chorioamnionitis and puerperal endometritis in patients with meconium-stained amniotic fluid.

Methods: Patients in labor at 36 weeks of gestation or greater with singleton pregnancies and meconium-stained amniotic fluid were randomized to receive either cefazolin, 1 g/1,000 mL, of normal saline (n = 90) or normal saline (n = 93) amnioinfusion. Rates of clinically diagnosed chorioamnionitis and endometritis and of suspected and culture-proven neonatal infection were determined.

Results: Between the study and control groups, the incidences of clinical chorioamnionitis (7.8% vs. 8.6%), endometritis (2.4% vs. 3.5%), aggregate intrauterine infection (10.0% vs. 11.8%), suspected neonatal infection (17.8% vs. 21.5%), and proven neonatal infection (0.0% vs. 2.2%) were not significantly different.

Conclusions: Prophylactic use of cefazolin in amnioinfusions did not significantly reduce rates of maternal or neonatal infection