Properties of unusual phospholipids: I. Synthesis, monolayer investigations and calorimetry of diacylglycerophosphocholines containing monoacetylenic acyl chains

✍ Scribed by Joachim Rürup; Martina Mannova; Gerald Brezesinski; Rolf D. Schmid

• Publisher: Elsevier Science
• Year: 1994
• Tongue: English
• Weight: 664 KB
• Volume: 70
• Category: Article
• ISSN: 0009-3084
• DOI: 10.1016/0009-3084(94)90086-8

✦ Synopsis

Isomeric diacylglycerophosphocholines containing various octadecynoic acids (4-, 6-, 9-, 12-, 14-and 17octadecynoic acid) were synthesized and purified to homogeneity. Their behaviour in monolayers, when studied by the Langmuir-Blodgett film balance technique, revealed systematic relationships between structure and packing properties. The thermotropic phase behaviour of these novel phospholipids, as measured by differential scanning calorimetry, depended in a systematic fashion on the position of the triple bond: the gel-to-liquid-crystalline phase transition temperature (Tin) passed through a minimum of -3.4°C for a triple bond in position 9.