Helothermine, a recently isolated toxin from the venom of the Mexican beaded lizard Heloderma horridum horridum was tested on K+ currents of newborn rat cerebellar granule cells. In whole-cell voltage-clamp experiments, cerebellar granule neurons exhibited at least two different K+ current component
Properties of the transient potassium currents in cerebellar granule cells
β Scribed by O. Zegarra-Moran; O. Moran
- Publisher
- Springer-Verlag
- Year
- 1994
- Tongue
- English
- Weight
- 714 KB
- Volume
- 98
- Category
- Article
- ISSN
- 0014-4819
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β¦ Synopsis
Macroscopic potassium currents were studied in cell-attached and inside-out patches from rat cerebellar granule cells. They were related with transient IA type potassium channels. Currents activated rapidly at potentials higher than -40 mV and did not inactivate completely. The magnitude of the current diminished when the membrane patches were excised. No differences in the activation and inactivation properties were found between patches in the integral cells and cell free membrane patches. A biophysical description of the currents is presented.
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