Properties of the microsomal and cytosolic glutathione transferases involved in hexachloro-1:3-butadiene conjugation
β Scribed by Franz Oesch; C.Roland Wolf
- Book ID
- 115780797
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- English
- Weight
- 731 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0006-2952
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π SIMILAR VOLUMES
Hexachloro-1,3-butadiene (HCBD) is more nephrotoxic to female than male rats. Metabolism of HCBD involves conjugation with glutathione followed by formation of the cysteine conjugate S-(pentachloro-1,3-butadienyl) cysteine (PCBD-CYS) and then the mercapturic acid N-acetyl-S-pentachloro-1,3-butadieny
## ABSTRACT Hexachloroβ1:3βbutadiene (HCBD) causes kidney injury specific to the __pars recta__ of the proximal tubule. In the present studies, injury to the nephron was characterized at 24βh following a single dose of HCBD, using a range of quantitative urinary measurements, renal histopathology a