Evaluation of cold-adapted adn temperatu
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Frances K. Crookshanks; Robert B. Belshe
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Article
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1984
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John Wiley and Sons
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English
β 395 KB
Cold-adapted (ca) and temperature-sensitive (ts) mutants of parainfluenza virus 3 were produced by serially passaging wild type (wt) parainfluenza virus 3 at 20 degrees C 45 times. Previously, plaque-purified viruses (clones) were selected from the wt parent and from cold passage levels 7, 12, 18, a