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Properties of mouse CD40. Ligation of CD40 activates B cells via a Ca++-dependent, FK506-sensitive pathway

โœ Scribed by Gerry G. B. Klaus; Michael S. K. Choi; Mary Holman

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
457 KB
Volume
24
Category
Article
ISSN
0014-2980

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๐Ÿ“œ SIMILAR VOLUMES

Properties of mouse CD40: the role of ho
Properties of mouse CD40: the role of homotypic adhesion in the activation of B cells via CD40
โœ Gerry G. B. Klaus; Mary Holman; Jhagvaral Hasbold ๐Ÿ“‚ Article ๐Ÿ“… 1994 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 693 KB

Stimulation of human Bcells via CD40 is known to induce their homotypic aggregation. We show here that anti-mouse CD40 monoclonal antibodies (mAb) also induce B cells to form large, spherical, extremely stable clusters. This clustering is markedly enhanced by co-stimulation with either interleukin-4