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Properties of Antigenomic Hepatitis Delta Virus Ribozyme cis- and trans-Analogues

✍ Scribed by L. Savochkina; V. Alekseenkova; T. Belyanko; M. Lukin; R. Beabelashvilli

Publisher: John Wiley and Sons
Year: 2005
Weight: 8 KB
Volume: 36
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.200506190

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## Abstract The self‐cleaving hepatitis delta virus (HDV) ribozyme is essential for the replication of HDV, a liver disease causing pathogen in humans. The catalytically critical nucleotide C75 of the ribozyme is buttressed by a trefoil turn pivoting around an extruded G76. In all available crystal