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Properties of 7-substituted deoxyguanosines formed by cis-diamminedichloroplatinum(II)

✍ Scribed by Asta Försti; Reino Laatikainen; Kari Hemminki


Book ID
113136927
Publisher
Elsevier Science
Year
1986
Tongue
English
Weight
657 KB
Volume
60
Category
Article
ISSN
0009-2797

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The combination of cis-diamminedichloroplatinum(ll) (CDDP) and 7-ethyl-I0-[4-( I -pipmidino)-I -piperidino]carbonyloxycamptothecin (CPT-I I), a topoisomerase-I inhibitor, has been shown to be synergistic in vitro and clinically active against several human cancers refractory to chemotherapy. To eluc