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Properties and Reactions of Substituted 1,2-Thiazetidine 1,1-Dioxides: Methylation of β-Sultams

✍ Scribed by Martin Müller; Hans-Hartwig Otto


Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
295 KB
Volume
324
Category
Article
ISSN
0365-6233

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The N-benzyl-and N-alkyl-substituted 1,2-thiazetidin-3-one 1,1-dioxides 1b ± d reacted readily with NH 3 and primary amines via ring opening. The reaction with NH 3 proceeded at À 788 3 room temperature yielding ring-opened adducts via nucleophilic attack of NH 3 at the sulfonyl group, whereas the r