Properties and applications of the (2-nitrofluoren-9-yl)methoxycarbonyl group

✍ Scribed by Bernd Henkel; Ernst Bayer

• Book ID: 105360075
• Publisher: John Wiley and Sons
• Year: 2001
• Tongue: English
• Weight: 130 KB
• Volume: 7
• Category: Article
• ISSN: 1075-2617
• DOI: 10.1002/psc.309

✦ Synopsis

Abstract

This paper presents a new protecting group, the (2‐nitrofluoren‐9‐yl)methoxycarbonyl group. Investigations on the properties of this new modification of the Fmoc‐system, such as the solvent‐dependant photochemical cleavage, and enhanced lability towards bases, are described, as well as UV‐kinetic measurements of the cleavage reaction. In addition, the incorporation of the (2‐nitrofluoren‐9‐yl)methoxycarbonyl group into two peptides, and a sequence‐dependant photochemical cleavage reaction are reported. Copyright © 2001 European Peptide Society and John Wiley & Sons, Ltd.