Proof of Safety in Toxicology Based on the Ratio of Two Means for Normally Distributed Data

Sample size determination for proving eq

Sample size determination for proving equivalence based on the ratio of two means for normally distributed data

✍ Dieter Hauschke; Meinhard Kieser; Edgar Diletti; Martin Burke 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 137 KB 👁 1 views

Equivalence trials aim to demonstrate that two treatments do not differ by more than a prespecified clinically irrelevant amount. We consider the problem when equivalence is defined in terms of the ratio of population means and the original (untransformed) data are normally distributed. Application