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Pronounced reduction of in vivo prostacyclin synthesis in humans by acetaminophen (paracetamol)

✍ Scribed by K. Grèen; V. Drvota; O. Vesterqvist

Book ID
119050951
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
224 KB
Volume
37
Category
Article
ISSN
0090-6980

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The effect of prostacyclin on acetaminophen-induced liver injury has been investigated in the mouse. Two structurally unrelated thromboxane synthetase inhibitors, OKY 1581 and benzyl imidazole, were also examined in order to investigate the role of the prostacyclinthromboxane balance in the developm