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Prompt tumor formation and maintenance of constitutive NF-κB activity of multiple myeloma cells in NOD/SCID/γCnull mice

✍ Scribed by Md. Zahidunnabi Dewan; Mariko Watanabe; Kazuo Terashima; Mizuho Aoki; Tetsutaro Sata; Mitsuo Honda; Mamoru Ito; Shoji Yamaoka; Toshiki Watanabe; Ryouichi Horie; Naoki Yamamoto


Book ID
118699783
Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
464 KB
Volume
95
Category
Article
ISSN
1347-9032

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Multiple myeloma (MM) is a fatal lymphoid malignancy that is incurable with conventional modalities of chemotherapy. Strong and constitutive activation of nuclear factor kappa B (NF-kappaB) is a common characteristic of MM cells. In our study we successfully target NF-kappaB with a novel NF-kappaB i