Hepatocarcinogenic activity of N-butyl-N
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A. Hagiwara; T. Murai; H. Yoshino; H. Goshima; S. Mori; A. Takashima; T. Shirai;
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Article
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1999
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John Wiley and Sons
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English
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Male F344 and Wistar Shionogi (WS) rats were treated with 0.05% N-butyl-N-(4hydroxybutyl)nitrosamine (BBN) for 20 weeks and then killed at week 36 (experiment 1). Although reduction of body weight increase was found, no effects on liver weights were noted. Formalin-fixed and paraffin-embedded liver